General Information

  • ID:  hor001882
  • Uniprot ID:  P04566
  • Protein name:  Vasoactive intestinal peptide
  • Gene name:  VIP
  • Organism:  Cavia porcellus (Guinea pig)
  • Family:  Glucagon family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cavia (genus), Caviidae (family), Hystricomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0032879 regulation of localization; GO:0045732 positive regulation of protein catabolic process
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HSDALFTDTYTRLRKQMAMKKYLNSVLN
  • Length:  28
  • Propeptide:  HADGVFTSDYSRLLGQLSARKYLESLIXXXXXXXXXXXXXXXXXHSDALFTDTYTRLRKQMAMKKYLNSVLN
  • Signal peptide:  NA
  • Modification:  T28 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Vipr2, VIPR1
  • Target Unid:  H0W0G2, A0A286XMQ0
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001882_AF2.pdbhor001882_ESM.pdb

Physical Information

Mass: 382766 Formula: C147H238N42O43S2
Absent amino acids: CEGIPW Common amino acids: L
pI: 10.32 Basic residues: 6
Polar residues: 9 Hydrophobic residues: 8
Hydrophobicity: -64.64 Boman Index: -6718
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 73.21
Instability Index: 2066.43 Extinction Coefficient cystines: 2980
Absorbance 280nm: 110.37

Literature

  • PubMed ID:  2340294
  • Title:  Purification and amino acid sequence of vasoactive intestinal peptide, peptide histidine isoleucinamide (1-27) and secretin from the small intestine of guinea pig.
  • PubMed ID:  3748846
  • Title:  Purification and amino acid sequences of dog, goat and guinea pig VIPs.
  • PubMed ID:  4004849
  • Title:  Guinea pig has a unique mammalian VIP